CYCLIN D1 MEDIATES PAIN BEHAVIOUR IN A RAT MODEL OF BREAST CANCER-INDUCED BONE PAIN BY A MECHANISM INVOLVING REGULATION OF THE PROLIFERATION OF SPINAL MICROGLIA

AimsThe involvement of cyclin D1 in the proliferation of microglia, and the generation and maintenance of bone cancer pain (BCP), have not yet been clarified.We investigated the expression of microglia and cyclin D1, and the Soda Siphons influences of cyclin D1 on pain threshold.MethodsFemale Sprague Dawley (SD) rats were used to establish a rat mo

IntroductionSyndromic surveillance aims at augmenting traditional public health surveillance with timely information.To gain a head start, it mainly analyses existing data such as from web searches or patient records.Despite the setup of many syndromic surveillance systems, there is still much doubt about the benefit of the approach.There are diver

A novel series structure is proposed based on cascade control for dominating a class of unstable processes with large delay-times.The modified structure consists mainly of one controller that exists in the inner loop, and the inner loop controller is devised on the basis of internal model control (IMC) principles.The outer loop setpoint tracking co